SKINNY GREEN CAPS

SCHEDULING STATUS:
S0

PROPRIETARY NAME (AND DOSAGE FORM):
Skinny Pill capsules

COMPOSITION:

Each capsule provides: %NRV
Coffea arabica  
(Green coffee bean extract standardized to provide 45% chlorogenic acid)50 mg*
Camellia sinensis  
(Green tea leaf extract standardized to 95% polyphenols)25 mg*
Garcinia gummi-gutta  
(Garcinia cambogia fruit extract standardized to 60% hydroxycitric acid)300 mg*
Ilex paraguariensis  
(Yerba mate leaf extract)50 mg*
Raspberry ketones25 mg*
Caffeine25 mg*
% Nutrient Reference Values (NRVs) for individuals 4 years and older  
*%NRV not established  

Other ingredients: Gelatine (capsule shell), magnesium stearate.
Sugar free

PHARMACOLOGICAL CLASSIFICATION:
Category D Complementary Medicines: Discipline Specific Traditional 33.7 – Combination product

PHARMACOLOGICAL ACTION:
In addition to caffeine, chlorogenic acid and quinides found in green coffee are thought to promote weight loss. A green coffee bean extract was shown to have an inhibitory effect on body fat accumulation and weight gain. Caffeine suppressed fat absorption, and chlorogenic acid was found to reduce hepatic triglyceride levels. The phenolic compounds, neochlorogenic acid and feruloylquinic acid were found to enhance hepatic carnitine palmitoyltransferase activity. Further research suggests green coffee extract reduced appetite by a small amount.

Early evidence indicates that a green tea extract rich in EGCG can increase calorie and fat metabolism. The caffeine, catechin, and theanine constituents of green tea might contribute to this effect. Caffeine increases resting energy expenditure (REE) and cellular thermogenesis. It also causes an increase in nonoxidative fatty acid turnover and lipid oxidation. The effects of caffeine on energy expenditure and lipid metabolism seem to be mediated by both sympathetic and nonsympathetic mechanisms. Green tea might also affect energy expenditure.

The active constituent in garcinina cambogia, hydroxycitric acid (HCA), seems to have weight loss properties. In vitro, HCA competitively inhibits the extramitochondrial enzyme adenosine triphosphate (ATP) citrate lyase, which is involved in the conversion of carbohydrate to fat (lipogenesis). Inhibition of this enzyme prevents cleavage of citrate to oxaloacetate and acetyl-CoA, limiting the availability of acetyl-CoA for lipogenesis.

Raspberry ketone is thought to inhibit expression of genes related to adipogenesis, preventing adipocyte differentiation and lipid accumulation. It is thought that raspberry ketone might increase lipid metabolism and reduce obesity by increasing norepinephrine-induced lipolysis and thermogenesis.

INDICATION:
Skinny Pill is indicated when a deficiency of the active ingredients exists.

CONTRA-INDICATIONS:
If you suffer from a chronic medical condition, use this product under the supervision of your healthcare practitioner. Diabetics should monitor blood sugar levels while using this product.

INTERACTION:
If you are taking chronic prescription medication, consult your health care practitioner before using this product. Discontinue use of this product 2 weeks prior to any planned surgical procedure.

PREGNANCY AND LACTATION:
Pregnant and breastfeeding women should avoid using this product.

DOSAGE AND DIRECTIONS FOR USE:
Adults: Take 1-2 capsules in the morning. Start with one capsule and increase the dosage to 2 capsules or as required. Do not take at the same time as any prescription medication – wait at least 2 hours. Do not take within 5 hours of bedtime. Maintain an adequate state of hydration. Do not exceed the recommended dosage. For best results, combine with a balanced, kilojoule-controlled diet and moderate exercise.

SIDE EFFECTS AND SPECIAL PRECAUTIONS:
Discontinue the use of this product where there is sensitivity towards any of the ingredients.

KNOWN SYMPTOMS OF OVERDOSE AND TREATMENT:
Use only as directed.

IDENTIFICATION:
Clear size 0 capsule with light brown powder.

PRESENTATION:
White and clear PET labelled bottle with 60 capsules.

STORAGE INSTRUCTIONS:
Store at or below 25º C. Protect from light and moisture. Keep out of reach of children.

REGISTRATION NUMBER/APPLICATION NUMBER:
This medicine has not been evaluated by the South African Health Products Regulatory Authority. This medicine is not intended to diagnose, treat, cure or prevent any disease.

NAME AND BUSINESS ADDRESS OF APPLICANT:
FutureThis (Pty) Ltd
Oxford Manor
Illovo
0860018022
www.futurethis.co.za

DATE OF PUBLICATION OF THIS PACKAGE INSERT:
March 2022

DISCIPLINE OF THE MEDICINE
Discipline Specific Traditional

REFERENCES
Greenberg, J. A., Boozer, C. N., and Geliebter, A. Coffee, diabetes, and weight control. Am.J.Clin.Nutr. 2006;84(4):682-693.
Jena, B. S., Jayaprakasha, G. K., Singh, R. P., and Sakariah, K. K. Chemistry and biochemistry of (-)-hydroxycitric acid from Garcinia. J Agric.Food Chem. 1-2-2002;50(1):10-22.
Morimoto C, Satoh Y, Hara M, et al. Anti-obese action of raspberry ketone. Life Sci 2005;77:194-204.
Zheng G, Sayama K, Okubo T, et al. Anti-obesity effects of three major components of green tea, catechins, caffeine and theanine, in mice. In Vivo 2004;18:55-62.